CODA Study

Comparing Outcomes of Drugs and Appendectomy (CODA) is a large-scale randomized clinical trial to evaluate two ways to treat uncomplicated appendicitisappendectomy and antibiotics—in patients at participating hospitals nationwide.

The CODA trial focuses on clinical outcomes—broadly agreed, measurable changes in health or quality of life—as well as the patient-reported outcomes (PROs) that matter most to patients. Results of this study will support an evidence-based approach to appendicitis care and help nearly 300,000 Americans each year make an important healthcare decision about this common condition.





The CODA Trial is funded through a Patient-Centered Outcomes Research Institute (PCORI) Award (1409-24099).