As a Patient Advisor collaborating with CERTAIN, you will likely hear a lot about the Patient-Centered Outcomes Research Institute (PCORI). Indeed many of you played an instrumental role in the recent submission of funding applications! In 2010, Congress passed legislation authorizing the establishment of the PCORI as a not-for-profit, non-government entity. The mission of PCORI is to help people make informed health care decisions and achieve better health outcomes. Central to this mission is funding and promoting research guided by patients, caregivers and the healthcare community. The establishment of PCORI provided a catalyst for change in how research questions are identified, how research studies are developed and how results are reported to inform decision-making. Specifically, PCORI promotes the involvement of patients, caregivers and patient representatives as collaborators on research teams; as reviewers for PCORI’s formal review process of research funding applications; and through submission of specific questions PCORI should consider for future funding. You can learn more about PCORI, including opportunities to provide input at a national level at www.pcori.org.