CISTO: Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer  

CISTO is an observational study comparing additional therapy with medicine verses removal of the urinary bladder for patients with non-muscle-invasive bladder cancer (NMIBC) that recurs after treatment with intravesical Bacillus Calmette-Guerin (BCG). This study is funded by the Patient-Centered Outcomes Research Institute (PCORI). We will evaluate our research question on a large scale in real world practice settings and examine patient-centered outcomes such as quality of life (QOL), disease progression, patient preferences, and caregiver burden.